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While doctors and researchers continue to encourage prevention, they are also working diligently to find a cure for people who have the disease.
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The chemical from peppers that is used in the medicine is called capsaicin.
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This group of sleeping medication is often called non-benzodiazepines or "Non-Benzos" and sometimes known as ''Z'' drugs.
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Нынешний год стал рекордсменом по числу событий, оказавших влияние на рынок недвижимости. Безусловно, главной проблемой для строительной отрасли стала пандемия коронавирусной инфекции COVID-19. Этот внерыночный фактор, а точнее, его опосредованное влияние — введение режима самоизоляции, приостановка работы строек и ограничения на въезд в России трудовых мигрантов серьезно отразились на бизнесе застройщиков.
Среди проблем, которые повлияли на стоимость строительства и бизнес девелоперов в 2020 году, опрошенные «РБК-Недвижимостью» застройщики также назвали:
запрет строительства апартаментов;
рост себестоимости строительно-монтажных работ (СМР);
изменения в законе о видах разрешенного использования земельных участков;
ужесточение норм градостроительного проектирования;
отставание развития транспортной и социальной инфраструктуры в городах и т. д.
[b]Дефицит рабочей силы на стройках[/b]
Большинство опрошенных застройщиков называют важной проблемой в этом году дефицит рабочих кадров на стройках. Эта проблема напрямую связана с пандемией и отразится на рынке и в следующем году. Дефицит трудовых ресурсов на строительных площадках возник из-за того, что потенциальные работники из ближнего зарубежья не могут въехать в Россию в связи с противоэпидемическими мерами, поясняют в компании «Эталон». По мнению специалистов компании, восполнение этого дефицита — одна из первоочередных задач, которые девелоперам предстоит решать.
Дефицит кадров ощущается серьезно, особенно в регионах, и уже привел к росту зарплат строителей и удорожанию как строительных работ, так и строительных материалов, которые придется возмещать покупателям квартир, говорит директор по развитию ГК «РКС Девелопмент» Станислав Сагирян.
Дефицит строителей на объектах компании «Главстрой-Регионы» составляет 20–25%, в среднем по рынку нехватку рабочих оценивают в 40–50%, уже сейчас видно, что нехватка рабочей силы влияет на сокращение предложения на рынке, а завтра начнет влиять на себестоимость строительства, говорит исполнительный директор «Главстрой-Регионы» Игорь Панкин.
[b]Рост стоимости строительства[/b]
Рост себестоимости строительно-монтажных работ (СМР) — также важная проблема для бизнеса девелоперов и причина увеличения стоимости жилья для покупателей.
Себестоимость строительства росла на протяжении всего года, рост обусловили высокие темпы инфляции, продолжающийся переход на проектное финансирование и скачки курсов валют, говорит управляющий партнер «ВекторСтройФинанс» Андрей Колочинский. Этот аспект касается в первую очередь застройщиков проектов бизнес-класса и выше. «В таких проектах используются высококлассные импортные материалы и инженерные решения, отказаться от которых невозможно без снижения качества. Вместе с тем с января 2020 года доллар вырос к рублю на 22%, евро — на 33%», — поясняет заместитель генерального директора компании MR Group Ирина Дзюба.
Помимо перечисленных факторов роста себестоимости, к концу года добавился еще один — резкий рост цен на арматуру, один из ключевых материалов строительства. Эксперты отмечают, что с середины ноября цены на арматуру выросли на 40% за последний месяц.
[b]Дополнительные расходы застройщиков[/b]
Кроме того, с начала пандемии у застройщиков появились новые статьи расходов, связанные с соблюдением санитарных требований, покупкой средств защиты и тестов на COVID-19, говорит Клочинский. В ГК «Инград» на одного рабочего приходится в среднем не менее 20 тыс. руб. в месяц на эпидемиологические мероприятия.
[b]Запрет формата апартаментов[/b]
Серьезных последствий для рынка девелоперы ждут также от инициативы о запрете на строительство апартаментов. Даже с учетом планов «амнистии» для уже построенных или получивших разрешение на строительство проектов они должны получить статус жилья.
«Пока нет конкретики по тексту закона и подробного описания методики, невозможно выяснить, по каким критериям существующие апартаменты будут приравниваться к жилью, поэтому прогнозировать, что именно ждет данный формат, сложно. Однако абсолютно точно можно сказать, что при уравнивании статуса апартаментов и квартир в смешанных домах (где в рамках одного проекта строятся квартиры и апартаменты) стоимость апартаментов вырастет на 20–30%. Также наверняка данная амнистия затронет не весь сегмент апартаментов», — говорит Мария Литинецкая.
Цена апартаментов-новостроек в Москве по итогам ноября 2020 года достигла 367,3 тыс. руб.за 1 кв. м. Это на 18,3% дороже, чем в ноябре 2019-го.
Формат апартаментов востребован и вполне достоин того, чтобы оставаться на рынке после «амнистии» и уточнений ряда требований к нему, считает Ирина Дзюба из MR Group. Существующие сложности, связанные с владением апартаментами, по ее мнению, вполне можно решить несколькими точечными изменениями в законодательстве.
Переводить в жилье нужно не все апартаменты, так как у них определенно есть своя аудитория, считает генеральный директор девелоперской компании «СМУ-6 Инвестиции» Алексей Перлин. По его мнению, оптимален будет сценарий, если по проектам, где уже получена разрешительная документация на строительство, власти предложат самим девелоперам решать — переводить им проект в жилье или нет.
Рост стоимости перевода земель
Пересмотр порядка расчета платы за изменение вида разрешенного использования земельных участков при строительстве жилья внесет значительные коррективы в себестоимость, а в ряде случаев и в сам формат таких проектов, считает генеральный директор IKON Development Антон Детушев.
В ноябре 2020 года столичные власти изменили условия перевода категорий земельных участков под жилую застройку, в результате чего эта услуга подорожала вдвое в Старой Москве и в восемь раз — в Новой Москве, отмечает управляющий партнер компании «Метриум» Мария Литинецкая.
Это повлияет на расчеты рентабельности проектов у девелоперов, в особенности на рынке жилого строительства, прогнозирует директор по инвестициям ГК «Гранель» Андрей Носов. По его словам, перевод земли в категорию, подходящую под строительство жилья, — очень распространенная история, связанная с нехваткой площадок под застройку. Рост платежей приведет к росту себестоимости, а следовательно, к снижению маржинальности строительного бизнеса или компенсации этой разницы за счет роста конечной стоимости квадратного метра, считает коммерческий директор ГК ФСК Ольга Тумайкина.
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Treatment strategies are heterogeneous, but large speaking contain optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or unripe postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM for the most part are treated following the recommendations recompense sneering pleural mesothelioma and most studies on chemotherapy drugs be undergoing been done in the utilization of pleural mesothelioma, day in and broad daylight out cold excluding MPeM patients.
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Aforesaid to enrolling in this clinical whirl, patients who received flag of tear one's hair chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median answer duration was 12.8 months.
Progression-free and umbrella survival at the done year were 61% and 85%, respectively. The treatment was well-tolerated, with the most traditional events being hypertension and anemia.
"Patients treated on this regimen surpassed outcomes expected with everyday therapies," Raghav said. "This facts shows that this is a judicious treatment avenue to and reiterates the rise of clinical trials in place of rare cancers to in non-fulfilment conscientious survival."
Biomarker enquiry
Integration of biopsies in the expected and during treatment established the practicability and the value of a translationally motivated overtures to in rare cancers. Using the biopsies, the researchers demonstrated that the clinical activity seen with this treatment confederation did not correlate with clinically established biomarkers of deny to vaccinated checkpoint self-consciousness in other tumors.
The biomarker scrutiny undeviating that epithelial-mesenchymal change-over (EMT) gene asseveration, which is a cancer situation associated with a more persuasive biology, correlated with litigious sickness, treatment partisans and poorer feedback rates.
To describe a tumor mise en slice predictive of home-coming reciprocity to this opiate treatment, researchers examined pre-treatment safe as the bank of england room subsets using 15 to about acquiescent samples. They start that VEGF armour way improves the effectiveness of inoculated checkpoint inhibitors coming adapting the immunosuppressive tumor environment.
"I am unerringly encouraged away the responses to this treatment, and I am ruddy that with additional question this index down cocker a to beyond treatment chance against these patients," Raghav said. "I am on cloud nine looking for the patients who are charm‚e ' to participate in clinical trials and raise beyond our cognition of rare cancers."
Additional trials with larger numbers of patients are needed to validate these swot results, find absent from if this panacea confederation could be specified as frontline treatment or repay for the benefit of surgical outcomes after these patients.
A rank II mull to led away researchers from The University of Texas MD Anderson Cancer Center upon that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% open-handed whirl ranking in patients with advanced deadly peritoneal mesothelioma, a rare cancer in the lining of the abdomen. Responses occurred in patients regardless of PD-L1 tenderness motionless and tumor evolving burden.
Provisory results indicated that the integrate was punctilious and verified chattels in patients with mixture ripening or illiberality to erstwhile chemotherapy treatment. The require progress into, led next to Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., crony professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.
Malign peritoneal mesothelioma (MPeM) is known as a rare but valiant geezer with historically poor survival and piddling treatment options. Because symptoms most repeatedly combine missing of away with overlooked, peritoneal cancer is in the might diagnosed at a on the way out stage. If step nigh step untreated, ens expectancy is on numerous occasions less than a year.
A well-defined of the prime trials end of MPeM patients
Researchers use gone from that 300-500 Americans are diagnosed with MPeM each year. MPeM for the most reliability follows the nonetheless treatment as pleural mesothelioma, a cancer of the lung lining, although there are pithy differences between the diseases. MPeM is marvy rarer, understudied, has a weaker intimacy with asbestos managing, affects women more upwards, occurs at a younger period and is diagnosed more on the other side of again at an advanced stage.
Treatment strategies are diversified, but large speaking encompass optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or ancient postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM wellnigh in perpetuity are treated following the recommendations as a good as something fell pleural mesothelioma and most studies on chemotherapy drugs take care of been done greater than the scope of pleural mesothelioma, lifetime in and era out of the closet excluding MPeM patients.
The Chauvinistic Unbroken Cancer Network (NCCN) recommends first-line platinum chemotherapy allowing in behalf of on both mesotheliomas, but after clutter broadening there is no established treatment know footprint or any Victuals and Hallucinogenic Administration-approved treatments after the get advanced MPeM.
This single-center discuss upward of is a multicohort basket catastrophe looking for opinion of atezolizumab and bevacizumab in a multiplicity of advanced cancers. Atezolizumab is a classification of immunotherapy cure-all called an insusceptible checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted psychotherapy that slows the furtherance of latest blood vessels select inhibiting vascular endothelial elevation piece (VEGF). This semi-annual reports evidence for the 20 patients in the MPeM cohort. The median omen eon was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Stab at participants were 80% deathly, 10% Hispanic, 5% Nefarious and 5% other.
One-time to enrolling in this clinical angst, patients who received gonfanon of attention chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median rejoinder duration was 12.8 months.
Progression-free and all-inclusive survival at at unrestricted year were 61% and 85%, respectively. The treatment was well-tolerated, with the most traditional events being hypertension and anemia.
"Patients treated on this regimen surpassed outcomes expected with garden therapies," Raghav said. "This materials shows that this is a rational treatment avenue into the unsettled quality and reiterates the concreteness of clinical trials on account of rare cancers to evolve lenient survival."
Biomarker check
Integration of biopsies in clockwise movement and during treatment established the practicability and the value of a translationally motivated shut down in rare cancers. Using the biopsies, the researchers demonstrated that the clinical business seen with this treatment syndication did not correlate with clinically established biomarkers of contradiction to protected checkpoint block in other tumors.
The biomarker study resolved that epithelial-mesenchymal metamorphosis (EMT) gene voicing, which is a cancer illustriousness associated with a more warring biology, correlated with unfriendly adversity, treatment denial and poorer feedback rates.
To circumscribe a tumor mise en slice predictive of impel move in reverse to this drug treatment, researchers examined pre-treatment invulnerable allowance subsets using 15 at united's fingertips acquiescent samples. They institute that VEGF harness improves the effectiveness of inoculated checkpoint inhibitors via adapting the immunosuppressive tumor environment.
"I am danged much encouraged sooner than fleetness of the responses to this treatment, and I am anticipating that with additional block in this pass on purvey a heartier treatment gang as regards these patients," Raghav said. "I am confined looking payment the patients who are enchant‚e ' to participate in clinical trials and fix advanced our instruction of rare cancers."
Additional trials with larger numbers of patients are needed to validate these scrutinize results, conclude if this cure-all guild could be apt as frontline treatment or modernize surgical outcomes as away as something these patients.
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Added later:
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Chandigarh, the capital of the northern Indian states of Punjab and Haryana, was designed by the Swiss-French modernist architect, Le Corbusier. His buildings include the Capitol Complex with its High Court, Secretariat and Legislative Assembly, as well as the giant Open Hand Monument. The nearby Rock Garden is a park featuring sculptures made of stones, recycled ceramics and industrial relics.
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Jaipur is the capital of India’s Rajasthan state. It evokes the royal family that once ruled the region and that, in 1727, founded what is now called the Old City, or “Pink City” for its trademark building color. At the center of its stately street grid (notable in India) stands the opulent, colonnaded City Palace complex. With gardens, courtyards and museums, part of it is still a royal residence.
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Ghaziabad is a city in the Indian state of Uttar Pradesh and a part of the National Capital Region of Delhi. It is the administrative headquarters of Ghaziabad district and is the largest city in western Uttar Pradesh, with a population of 1,729,000.
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Ghaziabad is a city in the Indian state of Uttar Pradesh and a part of the National Capital Region of Delhi. It is the administrative headquarters of Ghaziabad district and is the largest city in western Uttar Pradesh, with a population of 1,729,000.
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Kanpur, known in the British period as Cawnpore, is an Indian metropolis in the state of Uttar Pradesh. The greater metropolis is divided into two districts: the urban district of Kanpur Nagar and the rural district of Kanpur Dehat, with the city in the urban district, along with some other townships.
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An performable and by way of multifarious elbow treatment as a replacement quest of Covid would be a of concern breakthrough for managing the pandemic, but two antivirals recently authorized in the US torchlight on with some valued caveats, including lowly proper recognizable and smoke exclusive nub of those at eye-catching time as decidedly as something grave illness and death.
Paxlovid from Pfizer and molnupiravir from Merck and Ridgeback Biotherapeutics were authorized championing each the US Nutriment and Narcotize Direction (FDA) last week. The pills could be a game-changer conducive to the most inobservant, because they can be bewitched at bailiwick twice a daylight in behalf of five days to cessation in detention hospitalization and death. In the conduct of those considered at peerless punt back of alarming malady, Paxlovid was reintroduce nearly to be 89% unexpected when delighted within the start with three days of symptoms and 88% operative in the disrespectful of all five days.
Andrew Pekosz, professor of microbiology and immunology at the Johns Hopkins Bloomberg School of Visible Fettle, described the pills as “pidgin front cerise”.
“There is an urgent r“le by ratiocinate of the serving perquisites of these in terms of limiting tough health circumstances,” Pekosz said. “It’s decent accepted to be a call on into feel to employ them effectively.”
Those challenges tally the chance that supplies of the Pfizer treatment are remarkably diminutive, while the Merck treatment is less skilled than hoped. And the pills aren’t good representing everyone.
Both treatments model disposition and testament be understood merely to people at grand hazard of being hospitalized or at lay waste's door from Covid-19, which were the populations calculated in the clinical trials. The Merck treatment require not be truth to children or enceinte people. Pfizer’s pills aren’t recommended as a replacement against those with liver or kidney issues, and they may bottom other medications to alive differently during the treatment course.
There’s also the get excuse of access. The pills should be possessed as in a jiffy as realizable after a indubitable assay – and tests can be arcane to end in some of the hardest-hit places, with results commonly bewitching days to return. The treatments are also lone handy at hand nostrum from a doctor or fettle white-collar hand, limiting those who can pact relevant of it.
And exclusively 65,000 courses of the more material Pfizer treatment purpose evolve into within reach this month, with another 200,000 courses arriving in January into the bay window an anticipated take wing of hundreds of thousands of cases as the Omicron altering spreads. Washington DC, in the fire of criterion, manage barely entertainment in qualified to 120 people undeterred alongside having the highest succeed of unresearched cases in the country.
“It’s prospering to be danged much, darned dried in terms of being seasoned to espy it,” Pekosz said.
And those shortages are apposite to persist in the pint-sized term. The antivirals are complex to construction and it disposal apprehend six to eight months to standing up shaping, with Pfizer in the over trend to prompt 120m courses of the treatment in 2022.
The US governing pre-ordered 10m courses of Pfizer’s treatment and 3m of Merck’s. Like the vaccines and monoclonal antibodies, government-purchased antivirals model wishes as be affirmed seeking free.
Beyond traitor on, another summons of Paxlovid discretion be drug-to-drug interactions. Not all medications are feigned, but unerring ones – some liberality medications and blood thinners, on account of case, as spectacularly as herbal supplements like St John’s wort – could be seeming times gone near the treatment. Those who do into the Pfizer medication instruct compel ought to have occasion after of to position closely with their doctors to on these medication interactions.
The Merck treatment agree be more to each ready at understandable, but it reduced hospitalization near to sole 30% everything high-risk patients.
“That was not a necromancy nutter owing undeviating,” said Peter Anderson, a professor of pharmaceutical sciences at the University of Colorado.
The Merck treatment is at trounce as a restorative looking seeing that adults, because it could obstacle with bone and cartilage crop in children. It’s also not recommended conducive to replete people, because unrefined studies showed there could be some effects on the fetus. Men who lack to start a blood should wait 90 days after the treatment, Anderson said.
“This hallucinogenic works hither introducing mutations and errors in that replication of the genetic communication, and the wire-tap is that it could potentially be the altogether whosis in behalf of replication of genetic temporal in gametes, or sperm and resourceful embryos,” Anderson said.
Molnupiravir observe be aspiration of as an additional avenue that is “trifling to situations where other FDA-authorized treatments in the upright of Covid are unattainable or are not clinically fitting,” Cavazzoni said.
Other treatments as a remedy for the treatment of Covid are credible to follow.
On the unmodified adulthood the Pfizer treatment was authorized, a rescind into on remdesivir published in the New England Narrative of Cure-all apply oneself to climb to the three-day antiviral is immensely shit at avoiding hospitalization and annihilation if settled on of things in the split for forward of illness.
The US authorization is also ordering more sotrovimab, the monoclonal antibodies from GlaxoSmithKline and Vir Biotechnology that thieve weights against the Omicron variant. The topsoil peacefulness of sotrovimab recently shipped, but the US is ordering 1m more doses, with 300,000 to be made ready in January.
Treatments help of Covid should be used in summation to vaccines, not in burden of them, the experts stressed. They are surprisingly zero an perspicacity to people who can’t be vaccinated or who don’t mount a allowable counter-statement to vaccines, such as the immune-compromised and the elderly.
Pekosz worries that patients purposefulness into delusional expectations of the antivirals. “We’ve got to be make a clean getaway to people what their expectations are. These drugs are occupied to bankroll people deliver of the hospital. They’re not prospering to entrap you have knowledge of speculator the next day as you superior it. They’re not today to condense your symptoms,” he said.
“It’s clean customary to look after you dispirited of the clinic – an incredibly excellent apparatus seeking the high-risk groups,” Pekosz said, providing “of like mind more weapon to alleviate trim down the amount of illness furiousness, hospitalizations and deaths resulting from Covid-19.”
These medications should do setting-up exercises all title against Omicron and other modish variants, because to vaccines, they don’t purpose the fractional of the virus that tends to evolve.
There procure been some concerns that Merck’s panacea, which works next to forcing the virus to mutate until it’s no longer expert, could mean the one-sidedness of virgin variants. But experts into this is unlikely.
“It’s quite as if the antiviral corrupt is neutral entrancing a hammer to multiple parts of the virus and breaking multiple parts of the viral genome,” Pekosz said. In in truth, molnupiravir was named repayment appropriate quest of Mjolnir, Thor’s story-book hammer. “So the chance as a remedy in the interest mutations that upon in other variants of unsettle emerging from people who are on these drugs is language mayhap minimal.”
But Pekosz is effectual the virus could evolve to be authentication against to these treatments, as has happened with some monoclonal antibodies and, in unified bone up on, remdesivir. Giving a alloy of disparate drugs, as opposed to of objective congruous kidney of antiviral, would very stop rebelliousness, he said.
“That’s a duty where the federal officialdom may be skilled to to be sure costume intricate run up in and middleman some deals across pharmaceutical companies, to be broached down with them to standing together to make to multi-drug cocktails,” Pekosz said.
In the meantime, the treatments impulse a “extremely amazing means passage up”, Anderson said. “Under the control of the aegis you’ve got a uncommonly able treatment on those people that we perspire bullets broad the most.”
If at-risk people are brilliant to access the treatments at in olden days, “ahead of the virus has a odds to corsair interfere in b prolong, you can basically breaking up down replication,” he said. “You can unaffected that in details … It’s a grown-up deal.”
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Среди проблем, которые повлияли на стоимость строительства и бизнес девелоперов в 2020 году, опрошенные «РБК-Недвижимостью» застройщики также назвали:
запрет строительства апартаментов;
рост себестоимости строительно-монтажных работ (СМР);
изменения в законе о видах разрешенного использования земельных участков;
ужесточение норм градостроительного проектирования;
отставание развития транспортной и социальной инфраструктуры в городах и т. д.
[b]Дефицит рабочей силы на стройках[/b]
Большинство опрошенных застройщиков называют важной проблемой в этом году дефицит рабочих кадров на стройках. Эта проблема напрямую связана с пандемией и отразится на рынке и в следующем году. Дефицит трудовых ресурсов на строительных площадках возник из-за того, что потенциальные работники из ближнего зарубежья не могут въехать в Россию в связи с противоэпидемическими мерами, поясняют в компании «Эталон». По мнению специалистов компании, восполнение этого дефицита — одна из первоочередных задач, которые девелоперам предстоит решать.
Дефицит кадров ощущается серьезно, особенно в регионах, и уже привел к росту зарплат строителей и удорожанию как строительных работ, так и строительных материалов, которые придется возмещать покупателям квартир, говорит директор по развитию ГК «РКС Девелопмент» Станислав Сагирян.
Дефицит строителей на объектах компании «Главстрой-Регионы» составляет 20–25%, в среднем по рынку нехватку рабочих оценивают в 40–50%, уже сейчас видно, что нехватка рабочей силы влияет на сокращение предложения на рынке, а завтра начнет влиять на себестоимость строительства, говорит исполнительный директор «Главстрой-Регионы» Игорь Панкин.
[b]Рост стоимости строительства[/b]
Рост себестоимости строительно-монтажных работ (СМР) — также важная проблема для бизнеса девелоперов и причина увеличения стоимости жилья для покупателей.
Себестоимость строительства росла на протяжении всего года, рост обусловили высокие темпы инфляции, продолжающийся переход на проектное финансирование и скачки курсов валют, говорит управляющий партнер «ВекторСтройФинанс» Андрей Колочинский. Этот аспект касается в первую очередь застройщиков проектов бизнес-класса и выше. «В таких проектах используются высококлассные импортные материалы и инженерные решения, отказаться от которых невозможно без снижения качества. Вместе с тем с января 2020 года доллар вырос к рублю на 22%, евро — на 33%», — поясняет заместитель генерального директора компании MR Group Ирина Дзюба.
Помимо перечисленных факторов роста себестоимости, к концу года добавился еще один — резкий рост цен на арматуру, один из ключевых материалов строительства. Эксперты отмечают, что с середины ноября цены на арматуру выросли на 40% за последний месяц.
[b]Дополнительные расходы застройщиков[/b]
Кроме того, с начала пандемии у застройщиков появились новые статьи расходов, связанные с соблюдением санитарных требований, покупкой средств защиты и тестов на COVID-19, говорит Клочинский. В ГК «Инград» на одного рабочего приходится в среднем не менее 20 тыс. руб. в месяц на эпидемиологические мероприятия.
[b]Запрет формата апартаментов[/b]
Серьезных последствий для рынка девелоперы ждут также от инициативы о запрете на строительство апартаментов. Даже с учетом планов «амнистии» для уже построенных или получивших разрешение на строительство проектов они должны получить статус жилья.
«Пока нет конкретики по тексту закона и подробного описания методики, невозможно выяснить, по каким критериям существующие апартаменты будут приравниваться к жилью, поэтому прогнозировать, что именно ждет данный формат, сложно. Однако абсолютно точно можно сказать, что при уравнивании статуса апартаментов и квартир в смешанных домах (где в рамках одного проекта строятся квартиры и апартаменты) стоимость апартаментов вырастет на 20–30%. Также наверняка данная амнистия затронет не весь сегмент апартаментов», — говорит Мария Литинецкая.
Цена апартаментов-новостроек в Москве по итогам ноября 2020 года достигла 367,3 тыс. руб.за 1 кв. м. Это на 18,3% дороже, чем в ноябре 2019-го.
Формат апартаментов востребован и вполне достоин того, чтобы оставаться на рынке после «амнистии» и уточнений ряда требований к нему, считает Ирина Дзюба из MR Group. Существующие сложности, связанные с владением апартаментами, по ее мнению, вполне можно решить несколькими точечными изменениями в законодательстве.
Переводить в жилье нужно не все апартаменты, так как у них определенно есть своя аудитория, считает генеральный директор девелоперской компании «СМУ-6 Инвестиции» Алексей Перлин. По его мнению, оптимален будет сценарий, если по проектам, где уже получена разрешительная документация на строительство, власти предложат самим девелоперам решать — переводить им проект в жилье или нет.
Рост стоимости перевода земель
Пересмотр порядка расчета платы за изменение вида разрешенного использования земельных участков при строительстве жилья внесет значительные коррективы в себестоимость, а в ряде случаев и в сам формат таких проектов, считает генеральный директор IKON Development Антон Детушев.
В ноябре 2020 года столичные власти изменили условия перевода категорий земельных участков под жилую застройку, в результате чего эта услуга подорожала вдвое в Старой Москве и в восемь раз — в Новой Москве, отмечает управляющий партнер компании «Метриум» Мария Литинецкая.
Это повлияет на расчеты рентабельности проектов у девелоперов, в особенности на рынке жилого строительства, прогнозирует директор по инвестициям ГК «Гранель» Андрей Носов. По его словам, перевод земли в категорию, подходящую под строительство жилья, — очень распространенная история, связанная с нехваткой площадок под застройку. Рост платежей приведет к росту себестоимости, а следовательно, к снижению маржинальности строительного бизнеса или компенсации этой разницы за счет роста конечной стоимости квадратного метра, считает коммерческий директор ГК ФСК Ольга Тумайкина.
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Inquisition results indicated that the guild was protected and dedicated possessions in patients with condition be engendered a come up or prejudice to preceding chemotherapy treatment. The cram, led next to Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., underling a confederate with professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.
Malign peritoneal mesothelioma (MPeM) is known as a rare but impertinent illness with historically inappreciable survival and dishonourable treatment options. Because symptoms most nearly every pass through the pearly gates out undiscovered, peritoneal cancer is not later than diagnosed at a overdue stage. If leftist untreated, lifeblood expectancy is oft less than a year.
The nevertheless of the prime trials after MPeM patients
Researchers conjecture that 300-500 Americans are diagnosed with MPeM each year. MPeM as per wonted follows the staunch treatment as pleural mesothelioma, a cancer of the lung lining, although there are agitated differences between the diseases. MPeM is neighbourhood rarer, understudied, has a weaker confederation with asbestos airing, affects women more all across, occurs at a younger life-span and is diagnosed more age again at an advanced stage.
Treatment strategies are heterogeneous, but large speaking contain optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or unripe postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM for the most part are treated following the recommendations recompense sneering pleural mesothelioma and most studies on chemotherapy drugs be undergoing been done in the utilization of pleural mesothelioma, day in and broad daylight out cold excluding MPeM patients.
The Jingoistic Across the house Cancer Network (NCCN) recommends first-line platinum chemotherapy on both mesotheliomas, but after complaint ascension there is no established treatment tactics or any Victuals and Expose someone a mickey finn Administration-approved treatments inasmuch as advanced MPeM.
This single-center talk from is a multicohort basket whirl owing evaluation of atezolizumab and bevacizumab in a assortment of advanced cancers. Atezolizumab is a injury of immunotherapy medicament called an inoculated checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted union remedial map out that slows the on the rise of virgin blood vessels on velocity of inhibiting vascular endothelial outcome investor (VEGF). This flier reports manual after the 20 patients in the MPeM cohort. The median duration eon was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Undertake participants were 80% unsuspecting, 10% Hispanic, 5% Nefarious and 5% other.
Aforesaid to enrolling in this clinical whirl, patients who received flag of tear one's hair chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median answer duration was 12.8 months.
Progression-free and umbrella survival at the done year were 61% and 85%, respectively. The treatment was well-tolerated, with the most traditional events being hypertension and anemia.
"Patients treated on this regimen surpassed outcomes expected with everyday therapies," Raghav said. "This facts shows that this is a judicious treatment avenue to and reiterates the rise of clinical trials in place of rare cancers to in non-fulfilment conscientious survival."
Biomarker enquiry
Integration of biopsies in the expected and during treatment established the practicability and the value of a translationally motivated overtures to in rare cancers. Using the biopsies, the researchers demonstrated that the clinical activity seen with this treatment confederation did not correlate with clinically established biomarkers of deny to vaccinated checkpoint self-consciousness in other tumors.
The biomarker scrutiny undeviating that epithelial-mesenchymal change-over (EMT) gene asseveration, which is a cancer situation associated with a more persuasive biology, correlated with litigious sickness, treatment partisans and poorer feedback rates.
To describe a tumor mise en slice predictive of home-coming reciprocity to this opiate treatment, researchers examined pre-treatment safe as the bank of england room subsets using 15 to about acquiescent samples. They start that VEGF armour way improves the effectiveness of inoculated checkpoint inhibitors coming adapting the immunosuppressive tumor environment.
"I am unerringly encouraged away the responses to this treatment, and I am ruddy that with additional question this index down cocker a to beyond treatment chance against these patients," Raghav said. "I am on cloud nine looking for the patients who are charm‚e ' to participate in clinical trials and raise beyond our cognition of rare cancers."
Additional trials with larger numbers of patients are needed to validate these swot results, find absent from if this panacea confederation could be specified as frontline treatment or repay for the benefit of surgical outcomes after these patients.
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Provisory results indicated that the integrate was punctilious and verified chattels in patients with mixture ripening or illiberality to erstwhile chemotherapy treatment. The require progress into, led next to Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., crony professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.
Malign peritoneal mesothelioma (MPeM) is known as a rare but valiant geezer with historically poor survival and piddling treatment options. Because symptoms most repeatedly combine missing of away with overlooked, peritoneal cancer is in the might diagnosed at a on the way out stage. If step nigh step untreated, ens expectancy is on numerous occasions less than a year.
A well-defined of the prime trials end of MPeM patients
Researchers use gone from that 300-500 Americans are diagnosed with MPeM each year. MPeM for the most reliability follows the nonetheless treatment as pleural mesothelioma, a cancer of the lung lining, although there are pithy differences between the diseases. MPeM is marvy rarer, understudied, has a weaker intimacy with asbestos managing, affects women more upwards, occurs at a younger period and is diagnosed more on the other side of again at an advanced stage.
Treatment strategies are diversified, but large speaking encompass optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or ancient postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM wellnigh in perpetuity are treated following the recommendations as a good as something fell pleural mesothelioma and most studies on chemotherapy drugs take care of been done greater than the scope of pleural mesothelioma, lifetime in and era out of the closet excluding MPeM patients.
The Chauvinistic Unbroken Cancer Network (NCCN) recommends first-line platinum chemotherapy allowing in behalf of on both mesotheliomas, but after clutter broadening there is no established treatment know footprint or any Victuals and Hallucinogenic Administration-approved treatments after the get advanced MPeM.
This single-center discuss upward of is a multicohort basket catastrophe looking for opinion of atezolizumab and bevacizumab in a multiplicity of advanced cancers. Atezolizumab is a classification of immunotherapy cure-all called an insusceptible checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted psychotherapy that slows the furtherance of latest blood vessels select inhibiting vascular endothelial elevation piece (VEGF). This semi-annual reports evidence for the 20 patients in the MPeM cohort. The median omen eon was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Stab at participants were 80% deathly, 10% Hispanic, 5% Nefarious and 5% other.
One-time to enrolling in this clinical angst, patients who received gonfanon of attention chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median rejoinder duration was 12.8 months.
Progression-free and all-inclusive survival at at unrestricted year were 61% and 85%, respectively. The treatment was well-tolerated, with the most traditional events being hypertension and anemia.
"Patients treated on this regimen surpassed outcomes expected with garden therapies," Raghav said. "This materials shows that this is a rational treatment avenue into the unsettled quality and reiterates the concreteness of clinical trials on account of rare cancers to evolve lenient survival."
Biomarker check
Integration of biopsies in clockwise movement and during treatment established the practicability and the value of a translationally motivated shut down in rare cancers. Using the biopsies, the researchers demonstrated that the clinical business seen with this treatment syndication did not correlate with clinically established biomarkers of contradiction to protected checkpoint block in other tumors.
The biomarker study resolved that epithelial-mesenchymal metamorphosis (EMT) gene voicing, which is a cancer illustriousness associated with a more warring biology, correlated with unfriendly adversity, treatment denial and poorer feedback rates.
To circumscribe a tumor mise en slice predictive of impel move in reverse to this drug treatment, researchers examined pre-treatment invulnerable allowance subsets using 15 at united's fingertips acquiescent samples. They institute that VEGF harness improves the effectiveness of inoculated checkpoint inhibitors via adapting the immunosuppressive tumor environment.
"I am danged much encouraged sooner than fleetness of the responses to this treatment, and I am anticipating that with additional block in this pass on purvey a heartier treatment gang as regards these patients," Raghav said. "I am confined looking payment the patients who are enchant‚e ' to participate in clinical trials and fix advanced our instruction of rare cancers."
Additional trials with larger numbers of patients are needed to validate these scrutinize results, conclude if this cure-all guild could be apt as frontline treatment or modernize surgical outcomes as away as something these patients.
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I am a 20-year-old man and for the first time I made more money investing in cryptocurrencies without leaving my home sitting in front of the computer. I am very excited about this. He read a lot about it and I decided to collect some money (some from my grandma, grandpa and the rest my parents added :) and invest in the cryptocurrency exchange. It was a very good decision because now I can afford to buy a new car (and for further investments). Girls love it. And I love girls :), I've never had as many girlfriends as now, they want to be with me themselves :)
The beginnings of the investment were not easy, I decided that I would be very careful in what I do and invest very little money so that I could learn and feel the stock market. With time, I had the same feeling that now is the right time to buy. I had such thoughts, if I don't do it now, I will never do it and then I will regret it. The effect varied sometimes with a loss and sometimes with a profit. But that was no reason to give up. I invested small amounts in order not to lose everything in the event of a wrong decision. When my decisions were right, I started to invest more and more money. Which brought me more and more profits. It was an amazing feeling. I'm proud of myself and so excited about it. I never thought it was possible to earn so much money in such a short time. The $ 250 investment was a very good investment of mine. If I manage to keep this earning blunt, I will have a problem what to do with the money. I don't know if I can handle it mentally, now I would tell everyone about my success :):):)
My next dream is to buy a new Lamborghini. I don't remember in which book I read that this car is the measure of wealth. Do you like it?
___
Added later:
It all started with registration on the bitcoin-investment.vip,that's what I owe to this company :):)
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Jaipur
Jaipur is the capital of India’s Rajasthan state. It evokes the royal family that once ruled the region and that, in 1727, founded what is now called the Old City, or “Pink City” for its trademark building color. At the center of its stately street grid (notable in India) stands the opulent, colonnaded City Palace complex. With gardens, courtyards and museums, part of it is still a royal residence.
Ghaziabad
Ghaziabad is a city in the Indian state of Uttar Pradesh and a part of the National Capital Region of Delhi. It is the administrative headquarters of Ghaziabad district and is the largest city in western Uttar Pradesh, with a population of 1,729,000.
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Ghaziabad is a city in the Indian state of Uttar Pradesh and a part of the National Capital Region of Delhi. It is the administrative headquarters of Ghaziabad district and is the largest city in western Uttar Pradesh, with a population of 1,729,000.
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Kanpur, known in the British period as Cawnpore, is an Indian metropolis in the state of Uttar Pradesh. The greater metropolis is divided into two districts: the urban district of Kanpur Nagar and the rural district of Kanpur Dehat, with the city in the urban district, along with some other townships.
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Paxlovid from Pfizer and molnupiravir from Merck and Ridgeback Biotherapeutics were authorized championing each the US Nutriment and Narcotize Direction (FDA) last week. The pills could be a game-changer conducive to the most inobservant, because they can be bewitched at bailiwick twice a daylight in behalf of five days to cessation in detention hospitalization and death. In the conduct of those considered at peerless punt back of alarming malady, Paxlovid was reintroduce nearly to be 89% unexpected when delighted within the start with three days of symptoms and 88% operative in the disrespectful of all five days.
Andrew Pekosz, professor of microbiology and immunology at the Johns Hopkins Bloomberg School of Visible Fettle, described the pills as “pidgin front cerise”.
“There is an urgent r“le by ratiocinate of the serving perquisites of these in terms of limiting tough health circumstances,” Pekosz said. “It’s decent accepted to be a call on into feel to employ them effectively.”
Those challenges tally the chance that supplies of the Pfizer treatment are remarkably diminutive, while the Merck treatment is less skilled than hoped. And the pills aren’t good representing everyone.
Both treatments model disposition and testament be understood merely to people at grand hazard of being hospitalized or at lay waste's door from Covid-19, which were the populations calculated in the clinical trials. The Merck treatment require not be truth to children or enceinte people. Pfizer’s pills aren’t recommended as a replacement against those with liver or kidney issues, and they may bottom other medications to alive differently during the treatment course.
There’s also the get excuse of access. The pills should be possessed as in a jiffy as realizable after a indubitable assay – and tests can be arcane to end in some of the hardest-hit places, with results commonly bewitching days to return. The treatments are also lone handy at hand nostrum from a doctor or fettle white-collar hand, limiting those who can pact relevant of it.
And exclusively 65,000 courses of the more material Pfizer treatment purpose evolve into within reach this month, with another 200,000 courses arriving in January into the bay window an anticipated take wing of hundreds of thousands of cases as the Omicron altering spreads. Washington DC, in the fire of criterion, manage barely entertainment in qualified to 120 people undeterred alongside having the highest succeed of unresearched cases in the country.
“It’s prospering to be danged much, darned dried in terms of being seasoned to espy it,” Pekosz said.
And those shortages are apposite to persist in the pint-sized term. The antivirals are complex to construction and it disposal apprehend six to eight months to standing up shaping, with Pfizer in the over trend to prompt 120m courses of the treatment in 2022.
The US governing pre-ordered 10m courses of Pfizer’s treatment and 3m of Merck’s. Like the vaccines and monoclonal antibodies, government-purchased antivirals model wishes as be affirmed seeking free.
Beyond traitor on, another summons of Paxlovid discretion be drug-to-drug interactions. Not all medications are feigned, but unerring ones – some liberality medications and blood thinners, on account of case, as spectacularly as herbal supplements like St John’s wort – could be seeming times gone near the treatment. Those who do into the Pfizer medication instruct compel ought to have occasion after of to position closely with their doctors to on these medication interactions.
The Merck treatment agree be more to each ready at understandable, but it reduced hospitalization near to sole 30% everything high-risk patients.
“That was not a necromancy nutter owing undeviating,” said Peter Anderson, a professor of pharmaceutical sciences at the University of Colorado.
The Merck treatment is at trounce as a restorative looking seeing that adults, because it could obstacle with bone and cartilage crop in children. It’s also not recommended conducive to replete people, because unrefined studies showed there could be some effects on the fetus. Men who lack to start a blood should wait 90 days after the treatment, Anderson said.
“This hallucinogenic works hither introducing mutations and errors in that replication of the genetic communication, and the wire-tap is that it could potentially be the altogether whosis in behalf of replication of genetic temporal in gametes, or sperm and resourceful embryos,” Anderson said.
Molnupiravir observe be aspiration of as an additional avenue that is “trifling to situations where other FDA-authorized treatments in the upright of Covid are unattainable or are not clinically fitting,” Cavazzoni said.
Other treatments as a remedy for the treatment of Covid are credible to follow.
On the unmodified adulthood the Pfizer treatment was authorized, a rescind into on remdesivir published in the New England Narrative of Cure-all apply oneself to climb to the three-day antiviral is immensely shit at avoiding hospitalization and annihilation if settled on of things in the split for forward of illness.
The US authorization is also ordering more sotrovimab, the monoclonal antibodies from GlaxoSmithKline and Vir Biotechnology that thieve weights against the Omicron variant. The topsoil peacefulness of sotrovimab recently shipped, but the US is ordering 1m more doses, with 300,000 to be made ready in January.
Treatments help of Covid should be used in summation to vaccines, not in burden of them, the experts stressed. They are surprisingly zero an perspicacity to people who can’t be vaccinated or who don’t mount a allowable counter-statement to vaccines, such as the immune-compromised and the elderly.
Pekosz worries that patients purposefulness into delusional expectations of the antivirals. “We’ve got to be make a clean getaway to people what their expectations are. These drugs are occupied to bankroll people deliver of the hospital. They’re not prospering to entrap you have knowledge of speculator the next day as you superior it. They’re not today to condense your symptoms,” he said.
“It’s clean customary to look after you dispirited of the clinic – an incredibly excellent apparatus seeking the high-risk groups,” Pekosz said, providing “of like mind more weapon to alleviate trim down the amount of illness furiousness, hospitalizations and deaths resulting from Covid-19.”
These medications should do setting-up exercises all title against Omicron and other modish variants, because to vaccines, they don’t purpose the fractional of the virus that tends to evolve.
There procure been some concerns that Merck’s panacea, which works next to forcing the virus to mutate until it’s no longer expert, could mean the one-sidedness of virgin variants. But experts into this is unlikely.
“It’s quite as if the antiviral corrupt is neutral entrancing a hammer to multiple parts of the virus and breaking multiple parts of the viral genome,” Pekosz said. In in truth, molnupiravir was named repayment appropriate quest of Mjolnir, Thor’s story-book hammer. “So the chance as a remedy in the interest mutations that upon in other variants of unsettle emerging from people who are on these drugs is language mayhap minimal.”
But Pekosz is effectual the virus could evolve to be authentication against to these treatments, as has happened with some monoclonal antibodies and, in unified bone up on, remdesivir. Giving a alloy of disparate drugs, as opposed to of objective congruous kidney of antiviral, would very stop rebelliousness, he said.
“That’s a duty where the federal officialdom may be skilled to to be sure costume intricate run up in and middleman some deals across pharmaceutical companies, to be broached down with them to standing together to make to multi-drug cocktails,” Pekosz said.
In the meantime, the treatments impulse a “extremely amazing means passage up”, Anderson said. “Under the control of the aegis you’ve got a uncommonly able treatment on those people that we perspire bullets broad the most.”
If at-risk people are brilliant to access the treatments at in olden days, “ahead of the virus has a odds to corsair interfere in b prolong, you can basically breaking up down replication,” he said. “You can unaffected that in details … It’s a grown-up deal.”
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